One pot solution synthesis of cyclic oligodeoxyribonucleotides.
نویسندگان
چکیده
Several cyclic oligodeoxynucleotides with different base composition and size have been prepared from 5',3'-unprotected linear precursors, using a bifunctional phosphorylating reagent. The final deprotected oligomers have been characterized by 1H- and 31P-NMR. The present procedure is particularly useful for millimolar scale syntheses.
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ورودعنوان ژورنال:
- Nucleic acids research
دوره 18 9 شماره
صفحات -
تاریخ انتشار 1990